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Tuesday, August 5 • 9:30am - 5:00pm
W2: A Sophomore Organic Lab Research Experience: Distributed Drug Discovery (D3) for Neglected Diseases

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This workshop will introduce essential elements of Distributed Drug Discovery. D3 labs enable student engagement in the fundamental research process of observation, hypothesis/prediction and experimentation utilizing computational, synthetic and biological testing lab modules. You will consider known drug leads for the possible treatment of Leishmaniasis, form hypotheses, and computationally select new analogs with potential drug activity. You will then carry out the synthetic steps shown to make these six new compounds using simple, robust, reproducible procedures, and inexpensive equipment. The polymer-bound products will be cleaved and analyzed off-site and the results from your six N-acylated unnatural amino acids will be pro­vided following the workshop. You will also conduct a biological assay to screen potential antibacterials made in a student lab at IUPUI.


Martin O'Donnell

Indiana University Purdue University Indianapolis


Jacob Durrant

University of California - San Diego

William Scott

research scientist, IUPUI
Linking chemical education to finding drugs for neglected diseases

Tuesday August 5, 2014 9:30am - 5:00pm EDT
PAD 207/367
  Instrumentation  Laboratory